Bax or Bak regulate mitochondrial membrane permeability, forming pores through which cytochrome c leaks into the cytoplasm in order to bind with APAF-1.

What is Apoptosis?

This 3D biomedical animation is a bespoke production designed to complement lecture content for the first-year pathology module at the University of Dundee School of Medicine.

The animation relies on a simplified yet memorable visual language and multimedia principles to effectively communicate to first-year students a concise introductory overview of apoptotic processes and their clinical relevance.

Watch below or on YouTube for subtitles (viewing time: 4 minutes).

What the students said:

I just loved it, I wish there were more videos that explain other topics also.”

“I find this an extremely useful form of learning to coincide with the lecture material where it can often be hard to place the role of each stage within a process like Cell Apoptosis.”

“I feel this will be useful for any complicated processes that students (especially undergraduates) may not understand without it being visualised.”

Still from "What is Apoptosis?" 3D education biomedical animation
Still from "What is Apoptosis?" 3D education biomedical animation, highlighting the caspase cascade
Still from "What is Apoptosis?" 3D education biomedical animation, highlighting apoptosis's importance in growth and development
Still from "What is Apoptosis?" 3D education biomedical animation, highlighting a T-lymphocyte triggering the external apoptotic pathway
Still from "What is Apoptosis?" 3D education biomedical animation, highlighting pro- and anti-apoptotic proteins, Bax and Bak and BCL-2 and BCL-X
Still from "What is Apoptosis?" 3D education biomedical animation, showcasing pores in the mitochondrial membrane releasing cytochrome-c
Still from "What is Apoptosis?" 3D education biomedical animation, highlighting the apoptosome
Still from "What is Apoptosis?" 3D education biomedical animation, showing a cancer cell multiplying
Still from "What is Apoptosis?" 3D education biomedical animation, summarizing the topics covered in the animation
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